Hanna Mathéron 2018
This research project aims to investigate the prevalence and bacterial spectrum of peripartum infections in Sierra Leone at Masanga Hospital in the rural Tonkolili district. Sierra Leone has one of the highest maternal mortality ratios worldwide (717 per 100,000 live births), with infections and sepsis accounting for a significant proportion of maternal and neonatal deaths. Limited diagnostic capacity and widespread empirical antibiotic use may contribute to inappropriate treatment and rising antimicrobial resistance.
The study is designed as a prospective cohort study including approximately 270 pregnant or postpartum women presenting with signs of infection, as well as 50 neonates with suspected sepsis. Participants will be tested for a range of pathogens, including Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Treponema pallidum, Group B Streptococcus, hepatitis B and C, HIV, and malaria. Diagnostic methods include PCR testing, bacterial cultures, microscopy, and rapid diagnostic tests. Antimicrobial resistance patterns of key pathogens, particularly Group B Streptococcus and Neisseria gonorrhoeae, will also be assessed.
In parallel, a Knowledge, Attitude and Practice (KAP) study will be conducted among 200 pregnant women and 30 healthcare workers to evaluate awareness of infections in pregnancy and patterns of antibiotic use.
The project aims to generate essential baseline data on infectious causes and resistance patterns to inform targeted screening, prevention, and treatment strategies. Ultimately, this research seeks to reduce inappropriate antibiotic use, combat antimicrobial resistance, and lower maternal and neonatal morbidity and mortality in rural Sierra Leone.
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